Ketones

  • When there isn’t a sufficient level of available glucose — which is what the body uses for its main source of fuel — and glycogen levels are depleted, blood sugar and insulin are lowered and the body looks for an alternative source of fuel: in this case, fat.
  • This process can happen when a person fasting, after prolonged exercise, during starvation, or when eating a low-carb, ketogenic diet.
  • And when the body begins breaking down fats for energy like this, a process known as beta-oxidation, ketones are formed for use as fuel for the body and brain. This is known as ketosis.
  • People following a ketogenic diet specifically reduce their carbohydrate intake for this reason: to create ketones for energy.

Best Ketone Supplements

#1 Real Supplements Rated Best in 2020
Keto Diet Drops with BHB Exogenous Ketones - Dietary Supplement Made in USA - Fat Burner & Appetite Suppressant for Women & Men - Keto Liquid with Better Absorption than Keto Pills - Keto Weight Loss
  • PURE KETO BHB DROPS - Get the most effective Keto Supplement with 2000 mg of pure BHB (as goBHB)! Keto Nature is specially formulated to help you stay in ketosis even when you eat unhealthy snacks and to provide an effective weight loss support. Our liquid formula with high bioavailability will help you to achieve faster results and to reach your desired weight quickly. Experience the most healthy way to become fitter than ever!
  • HEALTHY WEIGHT LOSS - Low carb diet is hard, but it provides you with such amazing health benefits as reduced appetite, improved heart health due to "bad" cholesterol reduction, and weight loss, especially in the abdomen. Our diet drops with Exogenous Ketones help to avoid keto crash and enhance overall wellbeing so you could really enjoy the keto diet. It also boosts metabolism and effectively suppresses junk food cravings.
  • KETO DIET SUPPORT - Ketogenic diet and primary the lack of carbs may cause such symptoms as brain fog and fatigue. Keto Nature helps to normalize the vital level of BHB (the most abundant ketone body created by the liver), which serves as fuel for the brain, heart, and muscles in times when carbohydrates are in short supply. It helps to support a healthy weight loss, cognitive function, reduce fatigue, and boost mood.
  • ULTIMATE QUALITY - Keto Nature keto diet drops are formulated and made in the USA. Our tincture is 100% safe to use - it does not contain sugar (except for natural sweetness in Lime and Lemon), starch, wheat, gluten, yeast, or soy derivatives. It is also GMO-free and Cruelty-free. Be sure: our fat burner will provide only a positive impact on your health! Buy now and see for yourself!
  • BEST RESULTS GUARANTEED - Our advanced formula is designed to make our customers healthier and stronger in a natural way! We are sure that you will truly enjoy your renewed daily routine with Keto Nature. Your experience is vital for our work. We proudly stand behind our product and ready to face any requests you may have. If your experience below 5 stars - write to us, and we will help you as fast as we can.
#2 Real Supplements Rated Best in 2020
MCM Nutrition – Exogenous Ketones Supplement & BHB - Boosts Energy & Suppresses Appetite - Instant Keto Mix That Puts You into Ketosis Quick & Helps with The Keto Flu (Lemon Flavor - 15 Servings)
  • BHB RESTORES YOUR ENERGY, PUSHES PEAK PERFORMANCE & IMPROVES RECOVERY: Beta-Hydroxybutyrate (BHB) is your brain’s main energy source for ketosis! By fusing BHB & exogenous ketones, you unleash a ketosis supplement that renews your energy levels, enriches mental clarity & enhances recovery post-workout!
  • ACHIEVE KETOSIS IN 30-MINUTES & SUPPRESS YOUR APPETITE: Take control of your body, whether you’re keto or just intermittent fasting, this lemon-flavored mix will deliver ketosis in minutes! Best of all, it makes tracking your calories & managing your macros EASIER than ever, by reducing your appetite!
  • PEACE OF MIND FOR HIGH-CARB DAYS, REWARDS YOUR WEIGHTLOSS GOALS: Finally, your sacred cheat days don’t have to kick you out of ketosis! MCM Nutrition’s keto drink-mix gives you access to instant ketones so you maintain ketosis… even while you indulge little! You’ll wonder how you ever managed without it!
  • FIGHTS “KETO FLU” & SUPPORTS BLOOD SUGAR: It’s no secret, brain-fog & hunger weigh you down when getting back into ketosis! Skip the side-effects & unlock a ketosis drink containing the essential nutrients to achieve QUICK ketosis! Ketones also balance your blood sugar, leaving you with consistent energy levels!
  • 100-PERCENT SATISFACTION OR YOUR MONEY BACK: Keto supplements are nothing short of an investment into your own body and we understand that! That’s why we allow you to put our ketones to the test! If for any reason you are not satisfied, we will refund EVERY penny… so you have nothing to lose!
#3 Real Supplements Rated Best in 2020
Keto BHB Exogenous Ketone Supplement - Beta Hydroxybutyrate Ketone Salt, Keto Pills - 60 Capsules
1,896 Reviews
Keto BHB Exogenous Ketone Supplement - Beta Hydroxybutyrate Ketone Salt, Keto Pills - 60 Capsules
  • Vitamin Bounty Keto BHB is Ketogenic ROCKET FUEL!
  • SUPERCHARGE your Ketosis and get you into keto ultra fast! This is the boost you need.
  • PERFECT Dietary Supplement for KETO! Enjoy the immediate benefits of Beta Hydroxybutyrate with no bad taste.
  • Backed by Vitamin Bounty's world class support and integrity, our Keto BHB is the ultimate choice.
  • Each bottle of BHB is always MADE IN THE USA and tested for quality assurance and efficacy in a GMP facility.
Sale#4 Real Supplements Rated Best in 2020
5x Potent Apple Cider Vinegar Capsules with Mother + BHB SALTS Keto Diet Pills With MCT OIL, Fat burner & Weight Loss Supplement Formula Keto Pills For Women Men Appetite Suppressant ACV Detox Support
  • ✔️ Our Apple Cider Vinegar with Keto supplement will expedite your Weight loss journey! See a HUGE reduction in your weight and put your body into ketosis in less than 1 week! Works for both men and women.
  • ✔️ We have taken calorie burning to a whole new level, combining together powerful ingredients like apple cider vinegar with BHB salts and MCT oil to give you the perfect edge for your weight loss routine. This powerful combination with proper exercise will surely show results in no time, so you best say goodbye to all your excess fat! Here comes the Keto diet!
  • ✔️ POWERFUL APPETITE SUPPRESSANT & NATURAL DETOXIFIER: our apple cider vinegar plus keto dietary supplement contains anti-inflammatory and antioxidant properties that will give you a healthier lifestyle. It supports the body’s natural cleansing process, by stimulating the colon and bowel to flush away undigested waste, reduce bloating, and boost your metabolism.
  • ✔️ NON-GMO FORMULA: This formula is made in the USA in a GMP certified facility. It is all natural, non-GMO, and does not contain unneeded preservatives. Since quality and reliability is our highest concern, our formula is 3rd-party tested to ensure potency and purity. We include 1500mg of pure apple cider vinegar with mct oil and bhb salts per serving (750mg per vegetable capsule), with 120 capsules in each bottle to take all your worries away for 60 days!
  • ✔️ CARB BLOCKER: Not only do these keto pills with ACV help you suppress your hunger but at the same time put your body into ketosis, a burning state, which burns carbohydrates faster than you can imagine!
#5 Real Supplements Rated Best in 2020
Exogenous Ketone Supplement, Key Keto: Patented BHB Salts (Beta-Hydroxybutyrate) - Formulated for Ketosis, to Burn Fat, Increase Energy and Focus, Supports a Keto Diet. Strawberry Lemonade (208g)
  • INSTANT KETOSIS (15 SERVINGS) - It can take days to get into ketosis after a day of eating high carb, and weeks to keto-adapt. During that time, you can deal with fatigue, brain fog, lethargy, and weakness since you're not making enough ketones on your own yet. Cut that time down to minutes with Key Keto. Skip feeling like a zombie and enjoy the energy that comes with active ketones in your blood.
  • LASTING ENERGY - Exogenous ketones can dramatically increase your energy at any time of the day with no jitters, heart pounding, or nausea. Key Keto can get you going physically and mentally, and can help you power through even the toughest workout or the longest meeting.
  • QUALITY - KEY KETO contains the highest quality BHB salts (beta-hydroxybutyrate). Each serving comes with 11.1 grams of high-quality goBHB and each jar contains 340 grams of product, which gives you 20 full servings or 40 half scoop-servings of the best tasting Keto drink on the market. It's the perfect keto preworkout drink!
  • SIMPLICITY - Key Keto is easy to measure for each dose you take. Whether you need a half scoop for a little energy before work, or a full scoop before a workout or to get you back into ketosis after a carb refeed, our precise powder scoop has you covered. It's a perfect keto base to mix with water or your favorite drink, Key Keto powder dissolves perfectly in liquids with no grit, no chalk, and no aftertaste.
  • MADE IN THE USA - Key Keto's high quality, lab tested, precisely measured keto supplement is sourced and manufactured in the USA at an NSF & GMP certified facility. With Key Keto, you are promoting US businesses and supporting the innovation that fuels elite athletes, weekend warriors, and health-conscious people like you.
#6 Real Supplements Rated Best in 2020
Keto Science Real Ketones Powder Dietary Supplement, Sugar-Free Lemon Drink Mix, Supports Carb-Fighting Diet and Weight Loss, 5.3 oz. (15 Servings)
136 Reviews
Keto Science Real Ketones Powder Dietary Supplement, Sugar-Free Lemon Drink Mix, Supports Carb-Fighting Diet and Weight Loss, 5.3 oz. (15 Servings)
  • SUPPORTS WEIGHT LOSS: Ketones promote increased metabolism, weight loss and enhanced brain function
  • FOR A KETOGENIC LIFESTYLE: Promote ketosis and improve ketogenic performance for an active, on-the-go lifestyle
  • EASY TO MAKE: Just mix with water, shake, and enjoy the metabolism-boosting benefits
  • PROVEN FORMULA FOR RESULTS: Formulated with patented and proven GoBHB ketones that your body can put to work quickly
  • KETO & PALEO: Ketogenic and Paleo-friendly lemon flavored drink mix that’s sugar free
Sale#7 Real Supplements Rated Best in 2020
VitaRaw Exogenous Keto Pills - (3X Powerful Dose | 2100mg Keto BHB) Best Keto Burn Diet Pills - Advanced Ketones BHB Supplement - Max Strength Keto Diet Pills for Women + Men - 90 Capsules
248 Reviews
VitaRaw Exogenous Keto Pills - (3X Powerful Dose | 2100mg Keto BHB) Best Keto Burn Diet Pills - Advanced Ketones BHB Supplement - Max Strength Keto Diet Pills for Women + Men - 90 Capsules
  • ✅ WHY CAN'T I LOSE WEIGHT & KEEP IT OFF? Diet is key when it comes to weight loss, but with modern diets being so heavily carb loaded, our bodies are burning the carbs for fuel instead of our stored fat! This makes it very difficult to get rid of excess weight.
  • ✅ WHY IS VITARAW'S KETO BURN SUPPLEMENT THE ANSWER? There are many different ketone supplements on the market, how do you know which is right for you? It comes down to formulation and the dosage! Our powerful beta hydroxybutyrate formula is made with 2,100 mg of pure exogenous BHB ketones. These ketosis pills contain a perfect keto complex containing a powerful dose of ketogenic BHB salts. BHB salts been have shown to drastically enhance & prolong the state of ketosis - the fat shredding state.
  • ✅ YOU DO NOT HAVE TO SUFFER: Some diets can be brutal ... and Thats NOT a sustainable recipe for long term weight loss. With our optimally formulated, BHB keto capsules, you will encounter compelling results. Once in the state of ketosis you will experience lasting energy through out your day, a peak level of focus, and an added boost of endurance to conquer your toughest workouts.
  • ✅ REACH YOUR GOALS: Our ketogenic diet pills are extremely potent and powerful, they provide your body with the keto boost it needs to start slimming down and feeling energized. Let our keto pill reduce your cravings, kick start your metabolism, shred excess fat, and help you power through your longest days. Our bhb exogenous ketones will assist you in looking and feeling your best.
  • ✅ A BRAND YOU CAN TRUST: Our keto vitamins are scientifically formulated so that each diet pill we produce aims to provide you with effective results. Our ketones supplement is manufactured in a state-of-the-art facility here IN THE USA with non-GMO ingredients. You can be sure that you are getting the safest, purest, and highest quality keto supplements on the market. Our team of experts are always free to answer any questions you may have.
#9 Real Supplements Rated Best in 2020
Keto-Mojo 50 Blood Ketone Test Strips, Precision Measurement for Diabetes & Low-Carb Weight Loss, Monitor Your Diabetic & Ketogenic Diet for Nutritional Ketosis, Strips Work Only in Keto-Mojo Meters
  • INSTRUCTIONAL VIDEOS: Beware of the E-2 error – strips are not expired! Watch our instructional videos to optimize your testing results; videos on YouTube, our website, or here at Alpha XR/ketomojo; US-based Customer Support available to answer questions
  • ENDORSED BY: Leading ketogenic industry doctors, scientists, trainers, and researchers all recommend Keto-Mojo ketone strips for accurate testing
  • BEST IN CLASS CUSTOMER SUPPORT: Our knowledgeable, friendly, US-based support team is eager and ready to help you! Any issues, please don't hesitate to contact us via our company website
  • INCLUDES: (50) Keto-Mojo Blood Ketone Test Strips, (1) Code Chip; does not measure blood glucose; Note: These test strips are exclusively for use with the Keto-Mojo Meter
#10 Real Supplements Rated Best in 2020
Pruvit Keto//OS NAT – Raspberry Lemonade Charged (5 Single Serve Packets)
  • Facilitates quick absorption of ketones which allows a state of ketosis to be reached faster than ever for unrivaled results.
  • facilitates quick absorption of ketones which allows a state of ketosis to be reached faster than ever for unrivaled results.
  • facilitates quick absorption of ketones which allows a state of ketosis to be reached faster than ever for unrivaled results.
  • facilitates quick absorption of ketones which allows a state of ketosis to be reached faster than ever for unrivaled results.
#11 Real Supplements Rated Best in 2020
#12 Real Supplements Rated Best in 2020
Exogenous Ketone Supplement, Key Keto: Patented BHB Salts (Beta-Hydroxybutyrate) - Formulated for Ketosis, to Burn Fat, Increase Energy and Focus, Supports a Keto Diet. Lemon Lime Sherbet 15 Servings
251 Reviews
Exogenous Ketone Supplement, Key Keto: Patented BHB Salts (Beta-Hydroxybutyrate) - Formulated for Ketosis, to Burn Fat, Increase Energy and Focus, Supports a Keto Diet. Lemon Lime Sherbet 15 Servings
  • INSTANT KETOSIS (15 SERVINGS) - It can take days to get into ketosis after a day of eating high carb, and weeks to keto-adapt. During that time, you can deal with fatigue, brain fog, lethargy, and weakness since you're not making enough ketones on your own yet. Cut that time down to minutes with Key Keto. Skip feeling like a zombie and enjoy the energy that comes with active ketones in your blood.
  • LASTING ENERGY - Exogenous ketones can dramatically increase your energy at any time of the day with no jitters, heart pounding, or nausea. Key Keto can get you going physically and mentally, and can help you power through even the toughest workout or the longest meeting.
  • QUALITY - KEY KETO contains the highest quality BHB salts (beta-hydroxybutyrate). Each serving comes with 11.1 grams of high-quality goBHB and each jar contains 340 grams of product, which gives you 15 full servings or 30 half scoop-servings of the best tasting Keto drink on the market. It's the perfect keto preworkout drink!
  • SIMPLICITY - Key Keto is easy to measure for each dose you take. Whether you need a half scoop for a little energy before work, or a full scoop before a workout or to get you back into ketosis after a carb refeed, our precise powder scoop has you covered. It's a perfect keto base to mix with water or your favorite drink, Key Keto powder dissolves perfectly in liquids with no grit, no chalk, and no aftertaste.
  • MADE IN THE USA - Key Keto's high quality, lab tested, precisely measured keto supplement is sourced and manufactured in the USA at an NSF & GMP certified facility. With Key Keto, you are promoting US businesses and supporting the innovation that fuels elite athletes, weekend warriors, and health-conscious people like you.
#13 Real Supplements Rated Best in 2020
Perfect Keto Exogenous Ketones: Base BHB Salts Supplement. Ketones for Ketogenic Diet Best to Support Weight Management & Energy, Focus and Ketosis Beta-Hydroxybutyrate BHB Salt (Chocolate)
3,988 Reviews
Perfect Keto Exogenous Ketones: Base BHB Salts Supplement. Ketones for Ketogenic Diet Best to Support Weight Management & Energy, Focus and Ketosis Beta-Hydroxybutyrate BHB Salt (Chocolate)
  • Beta-hydroxybutyrate salts (BHB): Nutrition strategies that rely on carbohydrates always leave us needing more food. On the other hand, the ketogenic diet relies on and taps into your body’s stored fat for longer, more stable energy with no bonking. Many keto-lovers adopt this lifestyle because they love the mental clarity, focus, and productivity that they experience while in ketosis. Whether you’re full-time keto or not, our exogenous ketone is designed to support ultimate mental performance.*
  • Quick and easy ketosis: Perfect Keto exogenous ketones may help you get into ketosis. Our beta-hydroxybutyrates (BHB) formula was designed for those on a ketogenic diet. Perfect Keto supports raised blood ketone levels, improving athletic endurance, mental performance, and energy levels. Sustained ketosis has been shown to support healthy weight management*.
  • Easy to mix: The bhb ketones in our BASE keto drink mix dissolves easily in water, coconut milk, coffee and shakes. It's the best-tasting ketones powder out there, with none of that fake tangy taste you get from fillers and other artificial ingredients.
  • No additives: Perfect Keto BASE is a bhb supplement keto drink that provides keto salts. Check the labels of other exogenous ketone products and you'll find plenty of gums, binders, fillers and other junk. Not here. Nothing but pure, effective exogenous ketones supplement designed to optimize your ketogenic state
  • High quality ingredients: Perfect Keto Base contains high-quality beta hydroxybutyrate (BHB) that's been extensively lab tested for purity, quality and efficacy. Each container Perfect Keto BASE contains 15 servings of ketones that are instant to support your keto diet.
#14 Real Supplements Rated Best in 2020
KETO-MOJO Bluetooth Ketone & Glucose Blood Testing Kit + APP, 20 Test Strips (10 Each), 1 Meter, 10 Lancets, 1 Lancing Device, Monitor Your Ketosis & Ketogenic Diet
  • MORE THAN A METER - Your purchase comes with a free smartphone app where you can instantly sync your readings to your phone and track your ketones and glucose. The app automatically calculates your Glucose Ketone Index (GKI), an important measure of metabolic health.
  • GET RESULTS ON YOUR KETO DIET by testing for ketosis with the most advanced technology including Bluetooth integration. This dual test kit - both glucose and ketones - gives you greater insight into your diet and what foods may adversely affect your results. Test, Don't Guess!
  • TESTED AND RECOMMENDED BY EXPERTS - Leading keto experts, healthcare professionals and researchers trust and recommend KETO-MOJO for accurate testing of ketosis and diabetic monitoring. Our LIFETIME WARRANTY backs that up.
  • RESOURCES TO HELP YOU LIVE A KETO LIFESTYLE - Keto-Mojo provides you with more than just testing strips. We provide you with all the information you need to be successful on your low-carb or keto journey. We help you understand keto basics, testing basics, food basics, and more. We provide hundreds of FREE articles, videos, and recipes!
  • EXCELLENT CUSTOMER SUPPORT – Our customer support team is based in the US and all live a keto lifestyle. They are highly qualified and can help resolve any issues you have with your meter or strips. Note that no test strips sold on Amazon are expired. If you get an E-2 error, your date may not be set correctly. Contact our customer support team.
#15 Real Supplements Rated Best in 2020
Get Into Keto - Exogenous Ketone Beta Hydroxybutyrate (BHB) for Men and Women - Supercharge Ketosis & Manage Cravings, 60 ct
  • ⚡ GET INTO KETO FAST - Increase the Ketone Levels immediately in your body with Beta Hydroxybutyrate Ketone Salt Pills
  • ⚡ BEAT THE KETO FLU - It takes your body some time to adjust to ketosis. Get Into Keto will help you BEAT the keto flu!
  • ⚡ STRONGER & MORE POWERFUL - Ever have a cheat day on Keto and feel bad the next day? Worried that you will get kicked out of keto? WE have the solution!
  • ⚡ SUPERCHARGE KETO - Keto Pills with great results like a BHB Ketone drink, without any of the bad taste.
  • ⚡ MADE IN THE USA, and bottled in a GMP certified facility, Vitamin Bounty products are a worry-free choice.
#16 Real Supplements Rated Best in 2020
MCM Nutrition - Exogenous Ketones Supplement & BHB - Caffeine Free and Suppresses Appetite - Instant Keto Mix That Puts You into Ketosis Quick & Helps with The Keto Flu (Fruit Punch - 15 Servings)
  • BHB PROVIDES MENTAL CLARTIY, PUSHES PEAK PERFORMANCE & IMPROVES RECOVERY: Beta-Hydroxybutyrate (BHB) is your brain’s main energy source for ketosis! By fusing BHB & exogenous ketones, you unleash a ketosis supplement that subtly renews your energy levels, enriches mental clarity & enhances recovery post-workout!
  • ACHIEVE KETOSIS IN 30-MINUTES & SUPPRESS YOUR APPETITE: Take control of your body, whether you’re keto or just intermittent fasting, this Fruit Punch-flavored mix will deliver ketosis in minutes! Best of all, it makes tracking your calories & managing your macros EASIER than ever, by reducing your appetite!
  • PEACE OF MIND FOR HIGH-CARB DAYS, REWARDS YOUR WEIGHTLOSS GOALS: Finally, your sacred cheat days don’t have to kick you out of ketosis! MCM Nutrition’s keto drink-mix gives you access to instant ketones so you maintain ketosis… even while you indulge little! You’ll wonder how you ever managed without it!
  • FIGHTS “KETO FLU” & SUPPORTS BLOOD SUGAR: It’s no secret, brain-fog & hunger weigh you down when getting back into ketosis! Skip the side-effects & unlock a ketosis drink containing the essential nutrients to achieve QUICK ketosis! Ketones also balance your blood sugar, leaving you with consistent energy levels!
  • 100-PERCENT SATISFACTION OR YOUR MONEY BACK: Keto supplements are nothing short of an investment into your own body and we understand that! That’s why we allow you to put our ketones to the test! If for any reason you are not satisfied, we will refund EVERY penny… so you have nothing to lose!
Sale#18 Real Supplements Rated Best in 2020
Dr. Boz Keto BHB Powder [Exogenous Ketones Supplement] -Best Keto Supplement for Weight Loss - Keto Supplement | Keto Shake – Keto Diet BHB Powder - [Raspberry Lemonade 244g]
  • Supplement with DR.BOZ Keto BHB turns up your energy! Ketones fuel your body. Why doesn’t everyone burn ketones for energy? Because it’s hard to start that “fire.” Light your fire with DR.BOZ Keto BHB.
  • Burn Stored Fat As Fuel. This means: Burn KETONES. Losing weight is easy once you burn ketones for fuel. Let us help you start that fire with DR.BOZ Keto BHB.
  • Clear Brain Fog, Boost Mental Clarity.
  • DID YOU FALL OFF THE KETO-BANDWAGON? Hop back on with DR.BOZ Keto BHB.
  • It takes days to switch your body from burning glucose to ketones. Keto-adaptation happens after weeks of circulating ketones. Transitioning to keto-life is awesome once you get past the fatigue, brain fog, flu-symptoms, and weakness. Speed this transition up and cut down on those symptoms. Cut that time down to minutes with DR.BOZ Keto BHB. Skip feeling like a zombie and enjoy the energy that comes with active ketones in your blood.
#19 Real Supplements Rated Best in 2020
KEPPI Exogenous Ketones Chocolate BHB Powder Supplement: BHB Chocolate Ketones Formulated to Increase Energy, Burn Fat, Maintain Ketosis and Mental Focus
  • KEPPI EXOGENOUS KETONES - THE BEST KETO BHB SUPPLEMENT: Say goodbye to a carb rich diet that leaves you craving more food. With the ketogenic diet, you can fuel your body by drawing on naturally stored fats for more stable energy. Many keto enthusiasts love the mental focus, get-it-done productivity and improved energy levels that come with ketosis. Our Chocolate exogenous ketones drink is packed with BHB Salts for a great keto supplement to help you hit peak performance.*
  • CHOCOLATE KETONES SUPPLEMENT TO KICKSTART KETOSIS: Whether you are new to the ketogenic diet, or coming off a carb cycle, our keto salts boost ketone levels instantly. Designed for the keto diet, our beta hydroxybutyrate BHB ketone supplement supports raised blood ketone levels, improving aerobic endurance, brain function, and energy levels so you can crush the day, whatever comes at you! Ketosis has also been shown to support healthy weight management.*
  • TASTY CHOCOLATE KETO POWDER: Our all-natural exogenous chocolate ketones powder dissolves instantly into water, smoothies or your coffee. KEPPI KETO exogenous ketone salts are packed with sodium, potassium and magnesium BHB salts and contain 15 servings. Our ketone powder also helps get you into ketosis and avoid symptoms of the Keto Flu or carb cycling such as fatigue, bloating and headaches. Give yourself a keto boost with Keppi Keto BHB powder.
  • NO ADDED EXTRAS. JUST PURE KETO BHB SALTS: While some competitors pack their bhb exogenous ketones drinks with all sorts of nasty fillers, KEPPI only uses natural ingredients. Our tasty and effective exogenous ketones have no sugar, carbs, fat, fillers, binders, or gums - just pure BHB ketones that get you into ketosis fast and maintain your ketogenic state during the day. Our lab uses top quality manufacturing processes and is GMP certified and proudly American!
  • KEPPI, YOUR TRUSTED KETO DIET PARTNER: We have been in the health and wellness space for more than half our lives and use our ketogenic supplements on a daily basis. Pair our exogenous ketones booster with our other keto supplements like MCT Oil and Collagen Peptides for better focus, more energy and a fitter, healthier you. We stand by all our products, so if you're not completely satisfied with our keto supplements, send us a note and we'll do our utmost ensure you're a happy customer.
#20 Real Supplements Rated Best in 2020
How To Kickstart Your Keto
  • Amazon Prime Video (Video on Demand)
  • Corrina Rachel (Actor)
  • Corrina Rachel (Producer)
  • English (Playback Language)
  • English (Subtitle)

Ketone Facts and Benefits

Ketones, also known as “ketone bodies,” are byproducts of the body breaking down fat for energy that occurs when carbohydrate intake is low.

Here’s how it works:

  • When there isn’t a sufficient level of available glucose — which is what the body uses for its main source of fuel — and glycogen levels are depleted, blood sugar and insulin are lowered and the body looks for an alternative source of fuel: in this case, fat.
  • This process can happen when a person fasting, after prolonged exercise, during starvation, or when eating a low-carb, ketogenic diet.
  • And when the body begins breaking down fats for energy like this, a process known as beta-oxidation, ketones are formed for use as fuel for the body and brain. This is known as ketosis.
  • People following a ketogenic diet specifically reduce their carbohydrate intake for this reason: to create ketones for energy.

Exogenous ketones have become a popular nutritional supplement since their introduction in 2014.

Like with any new supplement, though, there tends to be a lot of misinformation that you have to sift your way through to find the reliable data. So, this article does the hard work for you and gets right to what the true benefits and drawbacks of exogenous ketones are.

We also cover what forms of ketones to consider, how they function in the body, and their role in future research.

What Are Ketones?

Ketones are fuel for the energy-generating mitochondria within the cells of our bodies. They are an alternative fuel source to glucose.1

Ketones are simple compounds because of their small molecular structure and weight. Specifically, they are organic (carbon-based) compounds that contain a central carbon atom double-bonded to an oxygen atom and two carbon-containing substituents, denoted by “R” .

Generic Ketone Structure

In humans, there are 3 different ketones produced by the mitochondria of the liver. These are also often referred to as ketone bodies 2.
The three ketones are:

  1. Acetone
    Acetoaceate ( also know as Acetoacetic Acid)
  2. Beta-Hydroxybutyric Acid (also known Beta Hydroxybuyrate or BHB). Other chemical names include 3-hydroxybutyric acid or 3-hydroxybutyrate.
  3. BHB is not technically a ketone since it contains a reactive OH-group in place of where a double-bonded oxygen normally would be as you can see in the diagram below. Yet, BHB still functions like a ketone in the body and converts into energy much like acetoacetate and acetone.

Exogenous Ketone Bodies Explained

Exogenous ketone bodies are just ketone bodies that are ingested through a nutritional supplement. Ketone bodies produced in the liver are more properly referred to as endogenous ketone bodies.

Exogenous = Originates from a source external from the body.
Endogenous = Originates from a source internal to the body.
Most supplements rely on BHB as the source of their exogenous ketone bodies. BHB is converted to acetoacetic acid with a small quantity converted to acetone through a acetoacetate decarboxylase waste pathway. Some of the acetoacetic acid will enter the energy pathway using beta-ketothialase, which converts acetoacetic acid to two Acetyl-CoA molecules.

Important note: Research is in its early stages and we need more data to understand the long-term effects of combining high blood ketone levels with high or moderate carbohydrate based diets.

We don’t yet fully understand what the long term effects of combining a non ketogenic diet with exogenous ketone supplements are. Research is in its early stages and more data is needed.

A common question is why BHB is the go-to ketone body for exogenous ketone supplements. The likely reason is a combination of its efficient conversion into energy and its ease of formulation. In other words, that it is easier to formulate BHB into a nutritional supplement. And the body efficiently converts BHB to acetoacetic acid, which effectively raises blood ketone levels.

 

Ketone Salts vs. Ketone Esters

Exogenous ketones of beta-hydroxybutyrate are available in two forms:

  1. Ketone Salts: Naturally-derived compounds that simply mix sodium (and/or potassium, or calcium) with BHB to improve absorption. Commercially available supplements are all made from ketone salts currently (includes KetoForce, KetoCaNa and Keto OS). These are also sometimes called “Ketone Mineral Salts” of “BHB Mineral Salts”.
  2. Ketone Esters: Synthetically-made compounds that link an alcohol to a ketone body, which is metabolised in the liver to a ketone. Ketone esters are used primarily in research for testing their efficacy in elevating ketone body levels. Yet, the first commercial Ketone ester drink will be available in 2018 by HVMN. Research esters are reportedly very unpleasant tasting which HVMN hopes to change.

Structure of a BHB Ester

The Ketone esters raise blood levels of beta-hydroxybutyrate to higher levels than the Ketone salts. There is also strong evidence that ketone esters are more effective than ketone salts as far as their physiological benefits go. It is not clear why this happens, but could be because of a difference in the absorption rate in the GI tract.

However, esters tend to be a little tougher to tolerate (due to gut distress after ingestion) and don’t have the most pleasant taste (as mentioned earlier).

Why use Exogenous Ketones?

Exogenous ketone supplements may provide a multitude of benefits. These include athletic performance enhancement, more efficient weight loss, cancer prevention, cognitive improvement and anti-inflammatory properties.

Weight Loss Goals

  • Appetite suppression: Appetite was measured in 10 males and 5 females after consuming a ketone ester (KE) or a dextrose (DEXT) drink . Desire to eat and perception of hunger dropped after both drinks, but the KE was 50% more effective for 1.5-4hrs. Insulin levels rose for both drinks but were 3x less with the KE drink after 30mins (Fig 2). The hunger hormone, ghrelin, was significantly lower between 2 to 4 hours after drinking the KE. In conclusion Ketone esters delay the onset of hunger and lower the desire to eat.
  • The fate of excess ketones: In the event someone has an excessive amount of ketones in the blood, the body (specifically the kidneys) will work as quickly as possible to filter out ketones via urine rather than converting them to adipose tissue.9 This is not to say that you can’t gain fat if you consume an exorbitant amount of exogenous ketones, but that they are less prone to be converted to fat than other nutrients.
  • More tolerable than MCT oil: MCT oil has been known to cause gastrointestinal distress in users, especially when taken in higher amounts. Exogenous ketones in the form of ketone salts, in comparison, are well-tolerated. Thus they enable one to avoid adverse GI events while providing the body with similar types of benefits. Figure 2 shows Ketone esters can be effective at reducing appetite. A combination of MCT oil and exogenous ketones may aid weight loss and allow a lower loading of ketone supplements, without the GI distress seen with MCT oil.

Performance Goals

  • Athletic enhancement: The improvement of energetic efficiency and fuel sparing mechanisms. Exogenous ketone supplementation could enhance both of these components of athletic performance. There is a promising outlook in this area for a variety of reasons:
    • Exogenous ketones induce acute ketosis, lasting for several hours. This is without needing to have depleted muscle glycogen stores. (Low muscle glycogen is well known to impair sustained physical performance).10.
    • The ‘carb-sparing’ effect from BHB suppresses the break down of muscle glycogen. This leads to lower lactate levels. When increasing exercise intensity, fat oxidation (burning) reaches a limit. At that point the muscle burns carbohydrates as fuel. But when consuming Ketone esters, the body does not make this switch. This suggests Ketones are being used instead. 11
    • Exogenous ketones cause the body to rely less on fat as fuel. Fat takes longer to metabolise for energy than muscle glycogen. This is why fatty acids are not the preferred fuel under heavy exercise. This could be useful for keto-adapted athletes performing high-intensity cardiovascular or strength training.12 This is particularly useful for the Keto-adapted athlete who wants to undergo high-intensity cardiovascular or strength training.
    • Ketone esters increase free carnitine whilst exercising (which seems to improve physical performance).
    • Exogenous ketones reduce the use of Branched-chain amino acids (BCAAs) as fuel (deamination). Consumption of a ketone ester drink reduced the rise in muscle BCAAs by 50% during exercise. 6
  • Improved cognition: Elevated plasma ketone concentrations divert the brain to utilize ketone bodies for synthesis of phospholipids, which drives growth and myelination. Normally, glucose would be the preferred substrate, which is much less efficient.14 BHB seems to act as a signal for neuronal pathways. These enhance synaptic plasticity, cognition and neuronal stress resistance. 15 In rat studies, ingestion of a ketone ester for 5 days improved their spatial learning and memory. 16.

 

Health & Longevity

  • Anti-carcinogenic properties: Data seems to suggest that exogenous ketones are an effective anti-carcinogen. The reason behind this is that cancer cells are unable to use ketone bodies effectively, unlike most healthy tissues in the body. In fact, dietary ketone supplementation has been shown to increase survival rates of mice with systematic cancer by as much as 70%.17
  • Neuroprotection: As humans age, the brain becomes more susceptible to neurodegeneration and subsequent conditions such as Alzheimer’s and Parkinson’s disease. Exogenous ketone supplementation appears to ameliorate the typical decline in cognitive function that comes with aging. The likely mechanism for this neuroprotective property is that ketone bodies reduce the inflammation and hyperexcitability that is normally exhibited as glucose metabolism declines in the brain.18, 19
  • Anti-Inflammatory properties: There is evidence that ketone bodies play a crucial role in reducing inflammation by inhibiting a specific class of proteins called inflammasones.20
  • Gene regulation profile change. There is evidence that gene sets can be up regulated or down regulated. Still early days but an example of this is a change in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (mHS) in rats on a ketogenic diet.

 

Mechanisms: How Exogenous Ketones Work

Exogenous ketones have a variety of physiological effects shortly after ingestion:

  • For starters, ingesting ketones (especially ketone esters) is an efficient way to elevate BHB in the blood by upwards of 2 mMol for nearly 8 hours (see Ref. 2). Ketone salts don’t appear to elevate BHB in the blood as efficiently (or significantly) as ketone esters do, though.
  • Exogenous ketone supplementation causes blood glucose to decrease significantly, likely due to the acute increase in insulin sensitivity. Therefore, exogenous ketones may present a potential therapy for type-2 diabetics via regulation of blood glucose.
  • Exogenous ketones also improve oxygen utilization, especially in the central nervous system (CNS).21 This effect decreases the likelihood of oxygen reaching potentially toxic levels in the CNS, which in turn has a number of other positive health ramifications (such as those discussed in the previous section).

Possible Downsides to Ketone Supplementation

As with almost any nutritional supplement, side effects and downsides are possible after consuming exogenous ketones. That being said, they tend to be rather benign and will most likely improve as exogenous ketone supplementation becomes more prominent. The most common side effects to be aware of when using exogenous ketones include:

Electrolyte Imbalance – The physiological reasoning behind electrolytes becoming depleted during a state of ketosis is due to lack of water retention and frequent urination. When supplementing with exogenous ketones, the acute state of ketosis will likely increase the frequency of urination, but it won’t deplete glycogen stores. Therefore, it may be useful to drink an electrolyte solution if you are urinating a lot after taking exogenous ketones, but it’s dependent upon how you feel.

Halitosis (bad breath) – If you’re on a ketogenic diet you are probably aware that as the body starts to metabolize fat, ketones can cause poor breath. There is very little one can do about this, it’s just the nature of the beast. Unfortunately, this can also arise when using exogenous ketones, but it’s not as lasting as when on a ketogenic diet. Chewing gum or mints is about the best option if it becomes a noticeable issue. This maybe caused by over consumption of the ketone supplement, tailoring the quantity consumed may prevent excess BHB being converted to acetone, which is likely excreted by the lungs.

Possible GI distress (flatulence) at exceptionally high doses – In the studies referenced in this article, exogenous ketones taken in large doses occasionally resulted in GI distress, especially flatulence. However, the cause of this is hypothesized to be due to the fact that ketones were mixed in a milky fluid that wasn’t very palatable. If you’re taking a nominal dose of exogenous ketones the likelihood of GI distress is rather low. Moreover, if some GI distress is prevalent, it should improve as you become accustomed to taking ketones.

Hypoglycemia: why not to be concerned – Taking exogenous ketones can drive blood glucose levels quite low, but you are not likely to feel the typical symptoms of hypoglycemia. This is because when ketone levels are high enough, they dominate as fuel in the brain; hence, you will feel just fine despite having low blood glucose. A highly-cited study by George Cahill, found elevated ketone levels could protect fasted participants when they were administered insulin to induce hypoglycemia.

 

Future Applications & Research

Most current research on exogenous ketones focuses on the health and longevity applications of their use.

Another area that is targeted, is the psychological benefits of exogenous ketones, especially with how they can help protect brain tissue from degradation. As mentioned earlier, this has implications for the prevention of conditions like Alzheimer’s disease, Parkinson’s disease, and epileptic seizures.

Hopefully, in the not-too-distant future research will also focus more on the athletic performance benefits of exogenous ketones, specifically with regards to resistance training and cardiovascular exercise. The data on each of these applications is very limited at this time.

Takeaways

Exogenous ketones are becoming a popular topic of research. Importantly, research aims to validate their various uses (physical performance, weight loss, neuroprotective effects etc.). While there is good research on many of these, more data is needed to provide conclusive evidence.

Exogenous ketones, especially Ketone esters, achieve ketosis without following a ketogenic diet. But they must be consumed regularly to maintain ketosis. If Ketones are readily available then they may be used preferential over carbohydrates and fats when exercising. Even in highly glycolytic (carbohydrate) activities, such as sprinting.

Exogenous ketones certainly appear to have strong health and longevity properties at this point, especially for reducing the risk of cancer and possibly preventing/reversing type-2 diabetes.

 


Real Supplements gives you the best Ketones on the market today. Our top-rated lists are fresh and current so you get the best options.

Real Supps Team

We needed to put together a site we could send our friends and clients to with confidence they were getting the most updated information.  We hope this site is used as a reference that will make your purchase easier and with as much knowledge as we can share.

With over 30 years experience in the health and fitness industry, we are a team of fitness bloggers and entrepreneurs, certified personal trainers and nutritionists contributing to bringing the most up-to-date content.  We send our friends and clients here for reference to new supplements and hope it serves as a reference site for you as well.

Amazon Best Rated Products - Last Updated on 2020-07-08.

DISCLAIMER: There are affiliate links on this page. This means that at no cost to you, we will receive a small commission if you purchase through our link.